Senior Bioprocess Engineer

hace 20 horas

Ciudad de México, Ciudad de México Vexxel A tiempo completo

We are looking for a
Senior Bioprocess Engineer
to lead the industrial scale-up and technology transfer of Vexxel's proprietary biotechnological process.

This is a hands-on, execution-driven role with a clear near-term objective: delivering a transfer-ready protocol to a Contract Manufacturing Organization (CMO) within the first 3 months.

The role is based in Mexico and works closely with external manufacturing partners.

What you will do

Upstream – Fermentation

  • Scale microbial fermentation processes from lab to pilot and industrial scale
  • Optimize media, feeding strategies, pH, dissolved oxygen, and temperature
  • Ensure batch-to-batch reproducibility and process robustness
  • Define and control critical process parameters

Downstream – Small molecules

  • Design and optimize downstream processes for microbial-derived small molecules
  • Select and optimize separation techniques (filtration, centrifugation, solvents)
  • Reduce cost per unit while maintaining quality and performance

Technology transfer & CMO collaboration

  • Develop clear, executable SOPs and full process documentation
  • Lead technology transfer to a Contract Manufacturing Organization
  • Support initial industrial batches and resolve scale-up issues
  • Drive continuous improvement post-transfer

Technical leadership & execution

  • Act as technical owner of the end-to-end bioprocess
  • Coordinate technicians, operators, and external CMO teams
  • Ensure SOP compliance, operational discipline, and quality standards
  • Identify execution gaps and elevate overall process performance

Key milestones

First 3 months

  • End-to-end process defined, documented, and ready for CMO execution

6 months

  • Stable and optimized process validated at external manufacturing scale

12 months

  • Continuous improvements in yield, cost, and scalability

Requirements (non-negotiable)

  • 7+ years of experience in industrial bioprocessing
  • Hands-on experience in microbial fermentation and downstream processing
  • Proven experience transferring processes to CMOs or third-party plants
  • Strong execution mindset and ability to deliver under tight timelines
  • High level of autonomy and ownership
  • On-site availability in Mexico
  • Fluency in English

Important note

This is not an academic or exploratory R&D role. We are looking for someone who has already taken bioprocesses to industrial scale and put them into production.

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